Formoterol is more effective than salmeterol in suppressing neutrophil reactivity
نویسندگان
چکیده
Formoterol suppresses neutrophil reactivity in vitro; in COPD, this may contribute to anti-inflammatory efficacy http://ow.ly/Qr9fE.
منابع مشابه
Comparison of the effects of two long-acting beta2-agonists on cytokine secretion by human airway epithelial cells.
BACKGROUND AND PURPOSE Long-acting beta2-agonists (LABAs) have proved to be useful in the management of asthma and prevention of exacerbations. LABAs can modulate inflammatory and repair processes in the airways of individuals affected by many respiratory disorders. This study assessed the effects of LABAs on the release of inflammatory mediators by bronchial epithelia. METHODS The effects of...
متن کاملFluticasone/formoterol combination therapy is as effective as fluticasone/salmeterol in the treatment of asthma, but has a more rapid onset of action: an open-label, randomized study
BACKGROUND The inhaled corticosteroid (ICS) fluticasone propionate (fluticasone) and the long-acting β2-agonist (LABA) formoterol fumarate (formoterol) are being made available as a combination product (fluticasone/formoterol, flutiform ®) in a single aerosol inhaler. This 12-week, open-label, randomized, active-controlled, parallel-group, multicentre, phase 3 study compared the efficacy and sa...
متن کاملComparative safety and effectiveness of long-acting inhaled agents for treating chronic obstructive pulmonary disease: a systematic review and network meta-analysis
OBJECTIVE To compare the safety and effectiveness of long-acting β-antagonists (LABA), long-acting antimuscarinic agents (LAMA) and inhaled corticosteroids (ICS) for managing chronic obstructive pulmonary disease (COPD). SETTING Systematic review and network meta-analysis (NMA). PARTICIPANTS 208 randomised clinical trials (RCTs) including 134,692 adults with COPD. INTERVENTIONS LABA, LAMA...
متن کاملSalmeterol, formoterol, and salbutamol in the isolated guinea pig trachea: differences in maximum relaxant effect and potency but not in functional antagonism.
BACKGROUND Formoterol and salmeterol are new long acting beta 2 adrenoceptor agonists. The maximum relaxant effect, potency and functional antagonism against carbachol induced contraction for salmeterol, formoterol and salbutamol have been compared in the guinea pig isolated trachea. In addition, the possibility of inducing a non-beta adrenoceptor mediated relaxation by salmeterol was studied. ...
متن کاملDifferent bronchodilating effect of salmeterol and formoterol in an adult asthmatic.
New long-acting beta 2-adrenoceptor agonists, salmeterol and formoterol, have recently been marketed for treatment of asthma, but studies comparing the clinical efficacy of the two drugs have not been published. We report on an asthmatic patient who had a striking difference in bronchodilating effect of the two drugs, formoterol being more effective than salmeterol both in immediate response an...
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عنوان ژورنال:
دوره 1 شماره
صفحات -
تاریخ انتشار 2015